Copper Storage Disease, technically known as canine copper hepatotoxicosis, is a condition involving the excessive accumulation of copper in the liver. This is a very serious disease with the potential of being fatal if left untreated. Certain breeds of dog have a greater risk, including Bedlington Terriers, Doberman Pinschers, Skye Terriers and West Highland White Terriers. These breeds may also have an increased risk of developing chronic hepatits and cirrhosis.
Copper storage disease may result from an abnormal binding of copper to certain proteins in the liver or abnormal secretion of copper in the bile. Symptoms may vary depending on the degree of liver damage, but generally may include ascites, bleeding from the gums or the nostrils, diarrhea, jaundice, vomiting, and weight loss. Diagnosis typically involves blood tests and sometimes a liver biopsy. Penicillamine is typically used in treatment to bind and increase urinary excretion of copper. Zinc acetate can also help to bind copper and prevent its absorption, and vitamin E may help to minimize liver damage. Dogs are also typically put on a low copper diet, and vitamin C should be avoided. |
